Search results for " encoded"
showing 3 items of 3 documents
Residual Stresses Induced by Cold Expansion of Adjacent and Cut-Out Holes
2012
Fatigue life of fastener holes can be enhanced via a cold-expansion process to introduce a compressive residual stress field around the hole edge and to reduce crack growth propagation. Considering that aerospace components contain multiple rows of holes, the present investigation focuses on the evaluation of the three-dimensional residual stress distribution in adjacent cold-expanded (CE) holes. The redistribution of residual stresses caused by a cut introduced between two adjacent holes was also investigated. Finite element (FE) analysis and experimental technique were used to assess the residual stress distribution in a 6082-T6 aluminum plate with two adjacent holes expanded sequentially…
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.
2011
Genome-wide association studies (GWAS) have defined over 150 genomic regions unequivocally containing variation predisposing to immune-mediated disease. Inferring disease biology from these observations, however, hinges on our ability to discover the molecular processes being perturbed by these risk variants. It has previously been observed that different genes harboring causal mutations for the same Mendelian disease often physically interact. We sought to evaluate the degree to which this is true of genes within strongly associated loci in complex disease. Using sets of loci defined in rheumatoid arthritis (RA) and Crohn's disease (CD) GWAS, we build protein-protein interaction (PPI) netw…
On the Measurement and Prediction of the Out-of-Plane Displacement Surrounding Cold-Expanded Holes
2010
Experimental measurements of the out-of-plane displacement surrounding cold-expanded holes in a 6082-T6 aluminum alloy were made with a 3D optical scanner using the technique of the encoded light-pattern projection in white light. The measured surface profiles have shown the thickness discontinuity along the hole edge due to the effect of the split in the sleeve. An analytical–numerical solution of the out-of-plane displacement is presented based on existing analytical models. Thus, the results given by the analytical model were then compared with the experimental data and with a finite element (FE) model that simulates the cold-expansion process. The location of the elastic–plastic boundar…